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Table 3 Remission Status and Complications Caused by Chemotherapy

From: Clinical symptoms and chemotherapy completion in elderly patients with newly diagnosed acute leukemia: a retrospective comparison study with a younger cohort

 

Total

Type of Leukemia-ALL

Type of Leukemia-AML

Variables

Younger

Group

(n = 183)

Elderly

Group

(n = 183)

p-value1

Adjusted

P3

Younger

Group

(n = 67)

Elderly

Group

(n = 19)

p-value1

Adjusted P4

Younger

Group

(n = 116)

Elderly

Group

(n = 164)

p-value1

Adjusted P4

Chemotherapy dropout

69 (37.7)

92 (50.3)

0.015*

-

20 (29.9)

9 (47.4)

0.154

-

49 (42.2)

83 (50.6)

0.167

-

Remission status2

  

0.013*

0.008*

  

0.415

0.422

  

0.018

0.010*

   Partial

38 (33.3)

46 (50.5)

  

17 (36.2)

5 (50.0)

  

21 (31.3)

41 (50.6)

  

   Complete

76 (66.7)

45 (49.5)

  

30 (63.8)

5 (50.0)

  

46 (68.7)

40 (49.4)

  

Complication caused by chemotherapy

            

   Mouth ulcer

31 (16.9)

23 (12.6)

0.238

0.728

13 (19.4)

3 (15.8)

1.000

0.899

18 (15.5)

20 (12.2)

0.424

0.642

   Gastrointestinal disorder

34 (18.6)

37 (20.2)

0.692

0.170

18 (26.9)

5 (26.3)

0.962

0.629

16 (13.8)

32 (19.5)

0.211

0.127

   Cardiotoxicity

1 (0.5)

13 (7.1)

0.001*

0.047*

0 (0)

1 (5.3)

0.221

-

1 (0.9)

12 (7.3)

0.017

0.068

   Liver damage

26 (14.2)

29 (15.8)

0.661

0.607

9 (13.4)

5 (26.3)

0.179

0.228

17 (14.7)

24 (14.6)

0.996

0.987

   Lung infection

53 (29.0)

90 (49.2)

<0.001*

0.024*

13 (19.4)

9 (47.4)

0.014

0.025

40 (34.5)

81 (49.4)

0.013

0.138

   Angina

89 (48.6)

74 (40.4)

0.115

0.698

33 (49.3)

8 (42.1)

0.582

0.827

56 (48.3)

66 (40.2)

0.182

0.669

   Intestinal infection

38 (20.8)

36 (19.7)

0.795

0.951

17 (25.4)

4 (21.1)

1.000

0.538

21 (18.1)

32 (19.5)

0.767

0.871

   Fungal infection

36 (19.7)

51 (27.9)

0.065

0.285

10 (14.9)

6 (31.6)

0.100

0.051

26 (22.4)

45 (27.4)

0.341

0.755

   Skin hemorrhage

48 (26.2)

29 (15.8)

0.013*

0.019*

14 (20.9)

4 (21.1)

1.000

0.689

34 (29.3)

25 (15.2)

0.004

0.015*

  1. 1 Chi-square test was used.
  2. 2 The remission status was for those patients who finished the whole chemotherapy.
  3. 3 Multiple logistic regression analysis that adjusted for smoking, alcohol use, lung infection, hypertension, diabetes, type of leukemia, platelet and bone marrow cellularity
  4. 4 Multiple logistic regression analysis that adjusted for smoking, alcohol use, lung infection, hypertension, diabetes, platelet and bone marrow cellularity
  5. * Indicates significant difference between two groups, p < 0.05.