G2/M cell cycle arrest rate is increased in cells treated with a combination of TSA/DAC and paclitaxel. (A) MDA-MB-231 cells were treated with paclitaxel, DAC, TSA, or a combination. The cell cycle status was detected by PI staining and flow cytometry analysis 48 hours after treatment. The data were obtained from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001 compared to control. (B) Flow cytometry data from one representative experiment.