ARHI re-expression enhances the inhibitory effects of paclitaxel in vitro and in vivo. (A) SKBr3 cells were treated with paclitaxel (P), TSA (4-15 nM), or a combination of both drugs. The inhibitory rate was detected by SRB assays after three days of culture. **P < 0.01, ***P < 0.001 compared to paclitaxel alone. (B) MDA-MB-231 xenografts were treated with liposomes, pcDNA3 vector/liposomes or ARHI/liposomes. PBS was used as a control. *P < 0.05 compared to control group. (C) MDA-MB-231 xenografts were treated with paclitaxel, ARHI-liposomes or a combination of paclitaxel and ARHI-liposomes. PBS was used as a control. *P < 0.05 compared to control group.