Figure 6From: Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity Genistein inhibits proliferation in colon cancer cells by promoting FOXO3 activity. Schematic representation of pathways targeted by genistein in colon cancer cells [7–9, 13, 21, 50]. Genistein promotes FOXO3 activity by inhibiting PI3K/Akt and stimulating FOXO3 interaction with p53. Downstream, genistein-mediated FOXO3 activity increases p27kip1 expression, which promotes cell cycle arrest and leads to inhibition of proliferation.Back to article page