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Figure 6 | BMC Cancer

Figure 6

From: Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity

Figure 6

Genistein inhibits proliferation in colon cancer cells by promoting FOXO3 activity. Schematic representation of pathways targeted by genistein in colon cancer cells [7–9, 13, 21, 50]. Genistein promotes FOXO3 activity by inhibiting PI3K/Akt and stimulating FOXO3 interaction with p53. Downstream, genistein-mediated FOXO3 activity increases p27kip1 expression, which promotes cell cycle arrest and leads to inhibition of proliferation.

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