Table 2 Growth inhibition by Nutlin-3a, Doxorubicin, Cisplatin and Methotrexate for the sarcoma cell lines
From: MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines
Mean IC50 ± SE(nM) | |||||
|---|---|---|---|---|---|
Drugs | OSA | T778 | U2OS | RMS13 | SaOS-2 |
Nutlin-3a | 527 ± 131 | 658 ± 138 | 1024 ± 485 | na | na |
Dox | 62 ± 77 | 62 ± 31 | 40 ± 35 | 14 ± 4 | 77 ± 12 |
Cis | 758 ± 592 | 1566 ± 1369 | 1037 ± 596 | 855 ± 143 | 4828 ± 4855 |
Mtx | 30 ± 9 | 59 ± 74 | 181 ± 153 | 106 ± 34 | 636 ± 806 |