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Table 2 Summary OR (95%CI) and I-squre for various contrasts of the MDM2 SNP309 polymorphism and tumor risk

From: MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis

Subgroup

No. comparisons

TG vs. TT

GG vs. TT

GG vs. TT/TG

GG/TG vs. TT

  

OR (95% CI)

I-squre (%)

OR (95% CI)

I-squre (%)

OR (95% CI)

I-squre (%)

OR (95% CI)

I-squre (%)

Total

78

1.10* (1.03-1.17)

51.7

1.25* (1.13-1.37)

66.9

1.18* (1.10-1.27)

55.1

1.14* (1.07-1.22)

62.2

Tumor site

         

   Breast

18

1.09* (1.00-1.19)

12.8

1.09 (0.96-1.24)

20.7

1.05 (0.94-1.17)

19.5

1.09* (1.01-1.17)

9.1

   Lung

10

1.06 (0.93-1.22)

64.8

1.21 (0.99-1.47)

67.8

1.12 (0.99-1.27)

42.7

1.10 (0.95-1.27)

72.4

   Ovarian

3

0.85 (0.63-1.16)

25.2

0.79 (0.48-1.28)

52.3

0.89 (0.63-1.25)

33.1

0.82 (0.57-1.18)

50.5

   Pancreatic

2

1.55 (0.98-2.46)

59

1.56 (0.66-3.68)

74.6

1.24 (0.68-2.24)

56.4

1.54 (0.90-2.65)

73

   Blood

4

1.08 (0.65-1.79)

79.4

1.11 (0.57-2.17)

80.3

1.09 (0.71-1.68)

63.8

1.10 (0.67-1.82)

81.6

   Brain

5

1.47* (1.06-2.03)

57.6

1.18* (1.08-3.03)

69.5

1.38 (0.94-2.01)

55.9

1.51* (1.10-2.07)

61.3

   Colorectal

6

1.14 (0.89-1.47)

51.2

1.05 (0.65-1.68)

74.4

1.00 (0.67-1.49)

70

1.13 (0.85-1.50)

65.5

   Esophageal

2

1.11 (0.86-1.43)

36

1.26 (0.92-1.72)

51.2

1.28 (0.97-1.69)

63.1

1.18 (1.00-1.41)

0

   Head-neck

4

0.92 (0.67-1.28)

71.6

1.01 (0.69-1.47)

72.3

1.11 (0.96-1.29)

1.7

0.94 (0.67-1.34)

77.8

   Liver

4

1.57* (1.18-2.09)

0

2.24*(1.57-3.18)

0

1.65* (1.25-2.17)

0

1.76* (1.34-2.31)

0

   Skin

4

1.00 (0.86-1.16)

0.4

1.05 (0.85-1.29)

1.2

1.05 (0.86-1.27)

0

1.01 (0.86-1.19)

26.6

   Stomach

5

1.03 (0.75-1.42)

72.2

1.54* (1.04-2.29)

76.4

1.49* (1.20-1.84)

53.2

1.18 (0.84-1.65)

77.6

   Uterus

8

0.95 (0.81-1.11)

0

1.34* (1.07-1.69)

5.3

1.26 (0.92-1.72)

51.2

0.81* (0.70-0.94)

0

   Other

3

0.98 (0.72-1.32)

14.6

1.14 (0.63-2.08)

66.8

1.16 (0.72-1.85)

62.6

1.02 (0.67-1.52)

55

Racial descent

         

   African

3

1.22 (0.80-1.86)

61.2

0.75 (0.40-1.41)

0

0.73 (0.39-1.36)

0

1.16 (0.80-1.70)

56

   European

34

1.05 (0.98-1.13)

34.8

1.13* (1.01-1.25)

40.8

1.10* (1.00-1.20)

30.8

1.08* (1.00-1.16)

42.1

   Asian

32

1.11 (0.99-1.24)

58.4

1.36* (1.18-1.56)

68.6

1.27* (1.15-1.40)

58.6

1.18* (1.05-1.32)

65.8

   Mixed

9

1.10 (0.91-1.32)

49.7

1.16 (0.86-1.56)

59.6

1.08 (0.88-1.35)

37.3

1.10 (0.92-1.32)

52.7

p53 mutation status

         

   Positive

7

1.09 (0.89-1.34)

0

1.17 (0.75-1.82)

59.4

1.09 (0.70-1.69)

70.3

1.12 (0.92-1.36)

0

   Negative

7

1.06 (0.85-1.30)

4.1

0.95 (0.72-1.25)

0

0.97 (0.76-1.22)

0

1.03 (0.85-1.25)

0

  1. *P value < 0.05 for significance tests of OR = 1
  2. ‡ P value = 0.056 for significance test of OR = 1