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Table 1 Concentration of MF needed to achieve 50% growth inhibition (IC50) of the cell lines studied and their doubling times (DT)

From: Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression

Origin

Cell Line

IC50 (μM)

DT (h)

N. System

IOMM-Lee

9.4 ± 1.2

13.9

N. System

U87MG

23.2 ± 0.0

36.9

Breast

MCF-7

17.7 ± 2.0

37.7

Breast

MDA-MB-231

29.2 ± 1.3

33.3

Prostate

LNCaP

14.1 ± 0.5

50.7

Prostate

PC-3

18.5 ± 2.0

30.7

Ovary

OVCAR-3

19.0 ± 1.3

55.7

Ovary

SK-OV-3

12.6 ± 0.1*

36.9

Bone

U-2OS

21.9 ± 2.3

29.2

Bone

SAOS-2

18.7 ± 3.2

49.2

  1. IC50 data are expressed as mean ± s.e.m of three experiments each one performed in triplicate. DT data are the result of one experiment performed in triplicate (see Additional file 1: Figure S1). *Date obtained from our previously published work [14]
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BMC Cancer

ISSN: 1471-2407

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