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Table 4 Effects of chemotherapy on overall survival (OS) of various patient subsets.

From: Systemic chemotherapy for treatment of advanced small bowel adenocarcinoma with prognostic factor analysis: retrospective study

 

Factors

N

HR

95% CI

p value

After IPTW

All factors

91

3.44

2.03 - 5.83

<0.001

Age (years)

<58

44

2.93

1.46 - 5.85

0.002

 

≥58

47

8.10

3.17 - 20.67

<0.001

Gender

Male

67

4.97

2.69 - 9.18

<0.001

 

Female

24

3.47

1.19 - 10.13

0.023

ECOG PS

0/1

54

3.93

2.03 - 7.63

<0.001

 

≥ 2

33

4.55

1.64 - 12.65

0.004

Primary site

Duodenum

71

3.10

1.76 - 5.44

<0.001

 

Jejunoileum*

20

NA

 

0.122

Histology

WD/MD

44

7.63

3.01 - 19.36

<0.001

 

Undifferentiated

38

2.76

1.35 - 5.66

0.006

Status

Recurrent

17

7.33

1.64 - 32.75

0.009

 

Metastatic

70

3.97

2.17 - 7.27

<0.001

Primary tumor

Resected

29

13.49

3.48 - 52.36

<0.001

 

Still present

62

2.61

1.44 - 4.75

0.002

No. of Metastases

1

50

6.13

2.96 - 12.71

<0.001

 

>1

37

3.21

1.40 - 7.38

0.006

Liver metastasis

Yes

39

4.29

1.65 - 9.43

<0.001

 

No

52

5.34

2.52 - 11.31

<0.001

Peritoneal metastasis

Yes

42

7.37

2.98 - 18.27

<0.001

 

No

49

3.16

1.64 - 6.09

0.001

IALN metastasis

Yes

41

3.06

1.36 - 6.89

0.007

 

No

50

5.22

2.56 - 10.65

<0.001

Lung metastasis

Yes

6

NA

 

0.486

 

No

85

4.53

2.62 - 7.82

<0.001

Bone metastasis

Yes

3

NA

 

0.809

 

No

88

4.6

2.78 - 7.92

<0.001

  1. * Deaths: 8/8 in the patient group not receiving chemotherapy; 7/12 in the patient group treated with chemotherapy.
  2. Abbreviations: ECOG PS, Eastern Cooperative Oncology Group Performance Status; NA, not available; WD, well-differentiated; MD, moderately differentiated; IALN, intra-abdominal lymph node.