The mRNA expression of P53 target genes is de-regulated in human melanoma. Supervised hierarchical cluster analysis was performed on P53 target genes significantly altered between melanoma and melanocytes. Similarity in the mRNA expression patterns between genes and between samples was measured using Manhattan distance. Distances between clusters represent the average distances between genes and samples in the cluster. Genes are coloured according to their expression level, where up-regulated expression is represented by red, down-regulated expression is represented by blue, and equal expression is represented by yellow. (A) Analysis of 56 differentially expressed genes in 82 metastatic melanoma patients compared to 8 melanocyte cell lines. (B) Analysis of 34 differentially expressed genes in 6 melanoma cell lines (IgR3, Mel-RM, Me1007, MM200, Sk-Mel-28, Me4405) compared to normal cells (melanocytes, FLOW2000, HDF1314).