Figure 2
From: MMP28 (epilysin) as a novel promoter of invasion and metastasis in gastric cancer
Overexpression of MMP28 protein in gastric cancer is correlated with tumor aggressiveness and poorer prognosis. (A) Representative images of immunohistochemical staining showing MMP28 is overexpressed in gastric cancer compared to normal tissues. (B) Semi-quantitative immunohistochemical analysis indicating MMP28 is significantly overexpressed in primary gastric carcinomas (2.08 ± 0.71) and lymph node metastases (2.36 ± 0.89) compared to normal tissues (0.94 ± 0.68, p < 0.01) in 30 paired samples. (C) Kaplan-Meier survival curves showing significantly reduced survival in subjects with high MMP28 expression (p < 0.01, log-rank test). Positive primary gastric cancer tissues were those classified as MMP28 moderate to strong (expression score of 2 and 3).