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Table 2 Cancer incidence density by diabetes and metformin using status

From: Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals

Cancer type†

Taiwanese population Incidence‡

Incidence density (95%CI) of study cohort (per 10,000 person-years)

  

Non DM

(n = 10491)

DM without medication

(n = 8130)

DM without metformin

(n = 4327)

DM with metformin

(n = 11390)

Total cancer

49.9

46.0 (39.5-52.6)ab

97.6 (86.9-108)ac

91.7 (76.6-107)bd

44.8 (38.6-51.0)cd

   Male

59.3

50.3 (41.0-59.6)ab

122 (104-139)ac

107 (84.9-130)bd

47.7 (39.0-56.4)cd

   Female

41.2

41.0 (31.9-50.1)ab

75.7 (62.6-88.8)ac

74.0 (54.1-93.8)bd

41.2 (32.4-50.1)cd

Esophagus

1.14

2.94 (1.28-4.60)

5.14 (2.62-7.66)

4.03 (0.81-7.26)

4.78 (2.74-6.83)

   Male

2.09

3.63 (1.11-6.15)

7.45 (3.05-11.9)

5.09 (0.10-10.1)

5.83 (2.78-8.89)

   Female

0.20

2.13 (0.04-4.21)

3.05 (0.38-5.73)

2.84 (-1.10-6.78)

3.52 (0.91-6.13)

Stomach

2.64

3.91 (1.99-5.83)

5.14 (2.62-7.66)

6.71 (2.55-10.9)

5.46 (3.28-7.65)

   Male

3.49

3.63 (1.12-6.15)

6.78 (2.58-11.0)

8.90 (2.31-15.5)

4.58 (1.88-7.29)

   female

1.86

4.23 (1.30-7.17)

3.67 (0.73-6.60)

4.26 (-0.56-9.09)

6.53 (2.98-10.1)

Colorectal

7.31

7.07 (4.50-9.64)ab

19.8 (14.9-24.8)ac

17.4 (10.7-24.1)bd

6.83 (4.39-9.27)cd

   Male

8.63

6.78 (3.35-10.2)a

23.6 (15.8-31.4)ab

12.7 (4.83-20.6)

9.57 (5.66-13.5)b

   female

6.06

7.40 (3.53-11.3)a

16.4 (10.2-22.6)b

22.6 (11.6-33.7)ac

3.52 (0.91-6.12)bc

Liver

6.55

5.88 (3.53-8.23)ab

24.3 (18.8-29.7)ac

18.7 (11.8-25.7)b

10.2 (7.24-13.2)c

   Male

9.25

8.64 (4.76-12.5)ab

32.3 (23.2-41.4)ac

29.1 (17.2-41.0)bd

12.5 (8.01-16.9)cd

   Female

3.90

2.65 (0.33-4.98)a

17.0 (10.7-23.3)a

7.10 (0.88-13.3)

7.54 (3.72-11.3)

Pancreas

0.99

2.45 (0.93-3.96)

5.14 (2.62-7.66)

4.70 (1.22-8.18)

4.78 (2.74-6.83)

   Male

1.17

2.72 (0.54-4.90)

5.42 (1.67-9.18)

5.09 (0.10-10.1)

5.41 (2.47-8.36)

   female

0.81

2.13 (0.04-4.21)

4.88 (1.50-8.27)

4.26 (-0.56-9.09)

4.02 (1.24-6.81)

  1. † ICD-9-CM also incorporates the A-code for cancer which was used in Taiwan in ambulatory care settings before the year 2000. Total cancer (140-208/A08-A14), esophagus cancer (150/A090), stomach cancer (151/A091), colorectal cancer (153-154/A093-A094), liver cancer (155/A095), pancreas cancer (157/A096).
  2. ‡ Age-gender-standardized cancer incidence per 10,000 persons (95% confidence intervals) in the Taiwanese Cancer Registry Annual Report for 2007.
  3. a, b, c, d: Statistical significance was estimated by using the overlap rule for 95% CIs. Where there is the same superscript it means that there is significant difference between the two groups.