Figure 4

Aging-related phenotypes in eIF5A2 transgenic mice. (A) Cumulative plot of body weight versus age of male eIF-5A2 transgenic mice (n = 11) and their wild-type siblings (n = 8). * P < 0.05. (B) Quantification of the mean body weight of 5-month-old male eIF-5A2 transgenic mice and wild-type littermates is shown in the left (p < 0.05), and the representative image of a 24-week-old transgenic mouse and wild-type sibling was shown in the right. The body size of the transgenic mouse was significantly smaller than its wild-type sibling (P < 0.05). (C) Kaplan-Meier survival curve of male transgenic mice (n = 29, red line) and wild-type controls (n = 35, blue line). (D) Comparison of wound healing rates between 4-month-old eIF5A2 transgenic mice (15 wounds in 5 transgenic mice) and their wild-type siblings (12 wounds in 4 mice). * P < 0.05. (E) Representative HE-stained section at day 4 post-wounding in an eIF-5A2 transgenic mouse (left) and its wild-type sibling (right). The ability of re-epithelialization in the edges of wound was remarkably reduced in the transgenic mouse compared with its wild-type control (indicated by arrows). (F) Chronic skin lesions in eIF-5A2 transgenic mice (indicated by arrows).