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Figure 3 | BMC Cancer

Figure 3

From: Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability

Figure 3

eIF-5A2 expression, cell proliferation and histopathological analysis of 12-week-old mice (magnification, 400 ×). (A) Top panel, eIF-5A2 immunostaining of liver and heart from transgenic and wild-type mice. Middle panel, proliferation was measured by using PCNA immunostaining and the percentage of PCNA positive cells in transgenic mice (46.2 ± 10.98) was comparable to that in wild-type littermates (37.87 ± 10.44, p > 0.05). Bottom panel, haematoxylin and eosin (H&E) staining of adult liver and heart tissues. (B) H&E staining of the transgenic and wild-type livers after 12-week alcohol treatment.

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