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Figure 4 | BMC Cancer

Figure 4

From: Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: Role of uric acid accumulation in gemcitabine-induced MICA/B expression

Figure 4

Allopurinol blocks DNA damage-induced MICA/B expression. PANC-1 cells were treated with uric acid crystals (250 μg/ml each), 5-FU (10 μM, gemcitabine (2 μM) or radiation (40 Gy) in the absence or presence of allopurinol (250 μg/ml). After incubation for 24 hr, the cells were harvested and analyzed for MICA/B expression by FACS (Black line, isotype control) (A) or for intracellular uric acid concentrations by using a colometric uric acid kit (B). The data represent the mean ± SD from one of two experiments with similar results. AP, allopurinol; MSU, uric acid crystals (monosodium urate); 5-FU, 5-fluorouracil; Gem, gemcitabine, IR, radiation.

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BMC Cancer

ISSN: 1471-2407

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