Mitochondrial targeted catalase suppresses invasive breast cancer in mice

BMC Cancer

Table 1 Breast tumor invasiveness in polyoma middle T (PyMT) transgenic mice positive or negative for mitochondrial targeted catalase (mCAT).

PyMT Genotype	Number of mice	Primary tumor incidence	Average Invasion Grade	Metastatic tumor incidence	Metastatic tumor burden^a
WT	23	100%	2.8 ± 0.5	85.4%	1.3 ± 0.3
mCAT	32	97%	1.8 ± 0.5*^b	56.0%**	0.1 ± 0.02***

a) Metastatic tumor burden expressed as mm² tumor/cm² lung. b) Significant at P ≤ 0.03*; P ≤ 0.05**, or P ≤ 0.01***.
Mice were from two separate experiments that were each terminated at 110 days of age.

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