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Table 1 Clinicopathological characteristics of GIST patients (n = 93) and soluble L1 concentrations

From: Circulating levels of cell adhesion molecule L1 as a prognostic marker in gastrointestinal stromal tumor patients

Characteristics

Absolute counts (%)

Median soluble L1 concentration (25th and 75th percentile (ng/ml))

Mean soluble L1 concentration ± SD (ng/ml)

p-value

Total

    

   GIST

93(38)

1.4 (0.8 and 2.7)

2.1 ± 2.4

 

   Controls

151(62)

0.5 (0.0 and 1.0)

0.7 ± 1.4

>0.001

GIST

    

   Sex

    

   Male

51 (54.8)

1.5 (0.8 and 2.7)

2.1 ± 2.6

 

   Female

42 (45.2)

1.3 (0.8 and 2.4)

2 ± 2.3

0.708

   Tumor size (cm)

    

   <2

8 (11)

1.4 (0.9 and 4.8)

2.9 ± 3

 

   2-5

21 (29)

1.7 (1 and 2.4)

2.2 ± 2.2

 

   5-10

21 (29)

1.2 (0.7 and 2.4)

1.9 ± 2.1

 

   >10

22 (31)

1 (0.4 and 2)

1.4 ± 1.4

0.305

   Mitotic count (per 50 HPF)

    

   <5

27 (48)

1.1 (0.6 and 1.9)

1.7 ± 2.1

 

   5-10

8 (14)

1.1 (0.7 and 2)

1.3 ± 0.8

 

   >10

21 (38)

1.7 (1.1 and 2.6)

1.9 ± 1.2

0.258

   Tumor location

    

   Stomach

52 (65)

1.4 (0.9 and 2.6)

2.0 ± 2.0

 

   Small intestine

23 (29)

1.5 (0.6 and 2.6)

1.8 ± 2

 

   Others

5 (6)

1.1 (0.5 and 3.2)

1.7 ± 1.5

0.921

   Resection margin

    

   R0

52 (76)

1.4(0.8 and 2.6)

2.1 ± 0.4

 

   R1/2

16 (24)

1.4(1.2 and 2.6)

2.0 ± 0.4

0.529

   Recurrence

    

   No

35 (45)

1.1 (0.8 and 1.7)

1.4 ± 1.2

 

   Yes

42 (55)

1.7 (0.9 and 3)

2.4 ± 2.3

0.049

   Imatinib

    

   No

35 (46)

1.4 (0.8 and 3.0)

2.4 ± 2.7

 

   Yes

41 (54)

1.5 (0.7 and 2.4)

1.6 ± 1.2

0.673

   Risk NIH criteria

    

   Very low

5(9)

1.2 (0.7 and 2.8)

1.7 ± 1.4

 

   Low

9(16)

1.1 (0.8 and 1.9)

1.4 ± 1.0

 

   Intermediate

9(16)

0.7 (0.3 and 2.4)

2.0 ± 3.0

 

   High

33(59)

1.5 (0.8 and 2.4)

1.7 ± 1.4

0.834

   Risk AFIP criteria

    

   Very low

5(9)

1.2 (0.7 and 2.8)

1.7 ± 1.4

 

   Low

11(20)

1.4 (0.9 and 2.2)

1.8 ± 1.4

 

   Intermediate

13(23)

0.7 (0.2 and 2.0)

1.9 ± 2.8

 

   High

27(48)

1.5 (1.0 and 2.6)

1.6 ± 1.1

0.717

  1. NIH: National Institute of Health; AFIP: Armed Forces Institute of Pathology
  2. Not all counts add up to the full number of included patients (n = 93), due to incomplete data. P-values were calculated by the Mann-Whitney-U and Kruskal-Wallis tests