Figure 6

NKD1 knockdown enhanced the invasive ability of lung cancer cells, while these could be ablated by anti-Dishevelled-1 antibody. Matrigel invasion assay showed that the normal group had fewer cells invading into the lower surface of the transwell filter than the group transfected with NKD1 siRNA in LTEP (A) and LK (B) lines (P < 0.05). In contrast, When DVL-1 specific antibody incubated with NKD1 siRNA in LTEP (A) and LK (B) lines, the invasive cell number was significantly reduced(P < 0.05).