Figure 3
From: HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop
In vivo tumorigenicity potential of P9WT and S3DN cells. (A) Nude and SCID mice were injected with WT and DN2 cells and tumors were assessed by immunohistochemical analysis. H&E stained paraffin sections of tumors generated from WT and DN2 cells were photographed at 100×. T (tumor) and M (muscle) indicate invasive growth of P9WT cells. (B) Tumor invasion bar graph. Tumors were designated as non-invasive, attached, or invasive and expressed as a percent of total tumors. * The 2-sided probability (p) ≤ 0.0006 comparing the tumor phenotype distribution of WT and NEO cells combined, with that of DN2 and DN5 cells combined.