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Figure 6 | BMC Cancer

Figure 6

From: Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells

Figure 6

Model of ROS-mediated cytotoxicity induced by celastrol. Celastrol facilitates ROS accumulation in tumor cells by inhibiting the activity of MRC complex I. ROS then induce apoptosis and necrosis by activating JNK and downregulating HSP90 client proteins including EGFR, AKT and CDK4. ROS also mediate cell growth arrest by inducing G2-M phase blockage in tumor cells after celastrol treatment.

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