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Table 2 Comparison of tumour growth rates

From: Growth of breast cancer recurrences assessed by consecutive MRI

Characteristic n Growth rate
b (10-3 days-1)
Actual doubling time
DTact (days)
P
Age at detectionL     
   < 59 y. (median) 18 2.01 (-1.41 - 5.77) 341 (-685 - 785) 0.79
   >= 59 y. 19 2.21 (-0.12 - 5.79) 343 (-6797 - 4470)  
Menopausal status     
   Pre- 7 2.73 (1.25 - 3.98) 293 (193 - 651)  
   Post-, with hormone therapy 3 -0.12 (-1.41 - 2.18) -685 (-6797 - 343) 0.14
   Post-, without HT 27 2.22 (0.18 - 5.79) 344 (129 - 4470)  
Personal history     
   No previous breast cancer 20 2.09 (-1.41 - 3.98) 284 (-6797 - 4470)  
   Ipsilateral recurrence 7 1.38 (1.10 - 2.22) 581 (344 - 710) 0.004
   Contralateral recurrence 10 3.56 (1.65 - 5.79) 221 (129 - 481)  
Contralateral recurrence     
   No 27 1.69 (-1.41 - 3.98) 390 (-6797 - 4470) 0.001
   Yes 10 3.56 (1.65 - 5.79) 221 (129 - 481)  
Treatment of primary breast cancer
Surgery     
   Breast-conserving surgery 15 2.12 (1.10 - 5.77) 355 (129 - 710) 0.19
   Mastectomy 2 4.02 (2.26 - 5.79) 237 (130 - 344)  
Radiotherapy     
   No 1 5.79 (5.79 - 5.79) 130 (130 - 130) 0.10
   Yes 16 2.17 (1.10 - 5.77) 349 (129 - 710)  
Chemotherapy     
   No 9 2.02 (1.10 - 5.79) 390 (129 - 710) 0.71
   Yes 8 2.24 (1.19 - 5.76) 344 (141 - 660)  
Hormonal therapy     
   No 11 2.26 (1.10 - 5.79) 344 (129 - 710) 0.90
   Yes 4 2.51 (1.19 - 5.76) 335 (141 - 660)  
Location of cancer     
   Inner 8 2.09 (1.10 - 5.79) 376 (129 - 785)  
   Central 5 2.89 (1.38 - 3.33) 293 (245 - 604) 0.70
   Outer 24 2.17 (-1.41 - 5.76) 330 (-6797 - 4470)  
Histology     
   Invasive carcinoma 33 2.21 (-0.12 - 5.79) 343 (-6797 - 4470) 0.17
   In situ carcinoma 4 0.75 (-1.41 - 5.76) 401 (-685 - 2643)  
Grade     
   SBR 1 13 2.00 (0.18 - 3.82) 409 (192 - 4470)  
   SBR 2 14 2.59 (-0.12 - 5.79) 273 (-6797 - 710) 0.17
   SBR 3 6 2.81 (1.10 - 3.35) 284 (234 - 785)  
Tumour initial volume     
   < 139 mm3 (median) 18 2.73 (0.91 - 5.79) 274 (129 - 817) 0.04
   ≥ 139 mm3 19 1.52 (-1.41 - 5.76) 399 (-6797 - 4470)  
Oestrogen receptors     
   < 90% (median) 15 2.22 (-0.12 - 5.77) 293 (-6797 - 4470) 0.75
   ≥ 90% 17 2.12 (0.91 - 5.79) 355 (130 - 817)  
Progesterone receptors     
   < 35% (median) 16 1.95 (-0.12 - 3.84) 318 (-6797 - 785) 0.44
   >= 35% 16 2.22 (0.18 - 5.79) 343 (129 - 4470)  
Ki67     
   < 7.5% (median) 13 2.18 (-0.12 - 5.77) 265 (-6797 - 4470) 0.67
   ≥ 7.5% 13 2.26 (1.10 - 5.79) 344 (130 - 710)  
Mitotic count     
   < 3.5 (median) 16 2.01 (0.18 - 3.98) 399 (192 - 4470) 0.17
   ≥ 3.5 16 2.81 (-0.12 - 5.79) 284 (-6797 - 785)