From: Growth of breast cancer recurrences assessed by consecutive MRI
 | Primary breast cancer | Recurrence of breast cancer | Ipsilateral recurrence | Contralateral recurrence | P |
---|---|---|---|---|---|
Characteristic | (n = 20) | (n = 17) | (n = 7) | (n = 10) | Â |
Age at detection (years) | Â | Â | Â | Â | Â |
   Median (range) | 56 (40-72) | 60 (44-78) | 57 (53-64) | 62 (44-78) | 0.61 |
Menopausal status | Â | Â | Â | Â | Â |
   Pre- | 6 (30%) | 1 (6%) | 1 (14%) | 0 (0%) |  |
   Post-, with HT | 3 (15%) | 0 (0%) | 0 (0%) | 0 (0%) | 0.11 |
   Post-, without HT | 11 (55%) | 16 (94%) | 6 (86%) | 10 (100%) |  |
Mutation | Â | Â | Â | Â | Â |
   BRCA 1 | 2 (10%) | 0 (0%) | 0 (0%) | 0 (0%) | 0.24 |
   BRCA 2 | 0 (0%) | 1 (5.9%) | 1 (14%) | 0 (0%) |  |
Delay between cancers | Â | Â | Â | Â | Â |
 |  | 10 (2 - 19) | 13 (9-19) | 8 (2-17) | .003 |
Histologic type of primary cancer | Â | ||||
   IDC/ILC |  | 12 (75%) | 6/7 (86%) | 6/9 (67%) |  |
   DCIS |  | 4 (25%) | 1/7 (14%) | 3/9 (33%) |  |
Treatment of primary breast cancer | Â | ||||
Surgery | Â | Â | Â | Â | 0.48 |
   Breast-conserving surgery |  | 15 (88%) | 7/7 (100%) | 8/10 (80%) |  |
   Mastectomy |  | 2 (12%) | 0/7 (0%) | 2/10 (20%) |  |
Radiotherapy | Â | 16 (94%) | 7/7 (100%) | 9/10 (90%) | 1 |
Chemotherapy | Â | 8 (47%) | 2/7 (29%) | 6/10 (60%) | 0.33 |
Hormonal therapy | Â | 4 (27%) | 1/6 (17%) | 3/9 (33%) | 0.60 |
Location of cancer | Â | Â | Â | Â | Â |
   Inner | 3 (15%) | 5 (29%) | 1 (14%) | 4 (40%) |  |
   Central | 4 (20%) | 1 (6%) | 1 (14%) | 0 (0%) | 0.43 |
   Outer | 13 (65%) | 11 (65%) | 5 (17%) | 6 (60%) |  |
Histology of new cancer | 1.00 | ||||
   Invasive carcinoma | 18 (90%) | 15 (88%) | 6 (86%) | 9 (90%) |  |
SBR 1 | 9 (50%) | 4 (22%) | 2 (33%) | 2 (22%) | Â |
SBR 2 | 5 (28%) | 9 (60%) | 3 (50%) | 6 (67%) | 0.51 |
SBR 3 | 4 (22%) | 2 (13%) | 1 (7%) | 1 (11%) | Â |
   DCIS | 2 (10%) | 2 (12%) | 1 (14%) | 1 (10%) |  |
Tumour size | Â | Â | Â | Â | Â |
   Maximum tumour diameter at pathologic review (mm) | 9 (0 - 28) | 10 (2 - 35) | 10 (2 - 18) | 8.5 (5 - 35) | 0.97 |
   Initial volume (mm3) | 244 (14 - 4837) | 121 (8 - 2806) | 121 (26 - 612) | 116 (8 - 2806) | 0.44 |
   Final volume (mm3) | 357 (36 - 4373) | 425 (68 - 4319) | 359 (100 - 1355) | 458 (68 - 4319) | 0.90 |
Hormone receptors | Â | Â | Â | Â | Â |
   Oestrogen receptors | 80 (0-100) | 95 (20 - 100) | 90 (60 - 100) | 100 (20 - 100) | 0.06 |
   Progesterone receptors | 30 (0 - 95) | 40 (0 - 95) | 25 (2 - 95) | 55 (0 - 90) | 0.99 |
Ki67 | Â | Â | Â | Â | Â |
   Median (range) | 6 (1 - 35) | 12 (2 - 40) | 12 (5 - 30) | 12.5 (2 - 40) | 0.09 |
Mitotic count | Â | Â | Â | Â | Â |
   Median (range) | 2 (0 - 31) | 7 (1 - 20) | 3.5 (1 - 10) | 9 (1 - 20) | 0.20 |