Effects of IMOS on tumor growth and metastasis of HCCLM3-RFP xenograft. (A) HCC growth was dramatically suppressed by IMOS treatment, especially at doses of 60 and 90 mg/kg/d after 3 weeks. (B) Tumor volumes in mice treated with IMOS at 30, 60, and 90 mg/kg/d were markedly smaller than the volume in sham-treated mice on day 30 (P < 0.01). (C-E) Lung and mesentery metastases were significantly inhibited by IMOS at doses of 60 and 90 mg/kg/d (P < 0.01 for both). (C) Representative fluorescent images and (D and E) statistical results of metastatic foci in lung and mesentery (P < 0.01).