Figure 4

Inhibitory effects of IMOS on HCCLM3 cell adhesion, migration, and invasiveness. (A) Representative images of adhesion cell (×200) and (B) HCCLM3 adhesion was markedly inhibited by IMOS at doses of 16, 32, and 64 mg/mL as compared with sham treatment. (C) Representative images of migration distances (×100) and (D) HCCLM3 migrations began to be significantly inhibited by 16 mg/mL IMOS after a 24-hour treatment, and by 4 mg/mL IMOS after a 48-hour treatment (P < 0.01). (E) Representative images of transmembrane cells (×200) after treatment with 0, 16, 32, and 64 mg/mL IMOS. (F) Invasiveness of HCCLM3 was inhibited by IMOS in a dose-dependent manner.