Figure 3
Cell cycle arrest and apoptosis induced by IMOS in HCCLM3, HepG2, and Bel-7402 cells. (A-C) Cell numbers at G2/M and S phases decreased dramatically in HCCLM3, HepG2, and Bel-7402 cells in a dose-dependent manner. (D-F) After exposure to 4, 16, and 64 mg/mL IMOS for 24 hours, the number of apoptotic cells of HCCLM3, HepG2, and Bel-7402 were significantly increased as compared with control cells. (G-I) After treatment for 48 hours, IMOS significantly induced apoptotic death in HCCLM3, HepG2, and Bel-7402 cells at doses from 16 to 64 mg/mL.