Effects of JP and Gem on animal tumor burden. Panc-1 cells (1 × 106) were injected orthotopically in SCID mice. Eight weeks after tumor cell injection mice were randomized and treated with PBS (control), JP, Gem and JP + Gem. Three mice in each group were sacrificed at 24 hours of therapy, with a mean tumor weight of 0.594 ± 0.08 g. The remaining mice were sacrificed after 2 weeks. Symbol * represents p < 0.05 verses control (CNTL).