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Figure 1 | BMC Cancer

Figure 1

From: Prospective evaluation of prognostic factors uPA/PAI-1 in node-negative breast cancer: Phase III NNBC3-Europe trial (AGO, GBG, EORTC-PBG) comparing 6 × FEC versus 3 × FEC/3 × Docetaxel

Figure 1

Design of the NNBC 3-Europe trial. Stratification and randomization schedule: C1 = stratification by type of risk assessment based on choice of the centre (type of risk assessment); C2 = stratification by risk status; S = Stratification by HER-2/neu-FISH result; R = randomisation (FE100C: 5-Fluorouracil 500 mg/m², Epirubicin 100 mg/m², Cyclophosphamide 500 mg/m², q3 wks; Doc: Docetaxel 100 mg/m², q3 wks.). += fresh tumour tissue for patients within the "biological UP pathway", additionally in all patients paraffin blocks for central review.

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