Figure 1
From: Inhibition of nuclear factor kappa-B signaling reduces growth in medulloblastoma in vivo
Pharmacological inhibition of NFκB in medulloblastoma cell lines. A: Dose Dependent Survival: Dose response of medulloblastoma cell lines (cell number normalized to control) to NFκB inhibitors: pyrrolidine dithiocarbamate = PDTC, diethyldithiocarbamate = DDTC, sulfasalazine = SAS, curcumin = CURC, bortezomib = BTZ. (n = 3) Drug applied on day 0, cell count day 3 B: Time dependent survival: Time course of Daoy and D425 cells in response to IC90 values of PDTC (cell number normalized to control). Daoy 325 nM PDTC; D425 350 nM PDTC. (n = 3) Drug was applied only once on Day 0 C: Apoptosis: Annexin V staining for apoptosis in cell lines after 3 days in culture with designated concentrations of PDTC (n = 3 or more)