Table 5 The distribution of PTEN, PIK3CA, BRAF and K-RAS mutations and loss of PTEN expression in the 186 adenocarcinomas available from EPIC Norfolk.

BRAF mutant

BRAF wildtype

K-RAS mutant

3.4 (1)

25.5 (40)

K-RAS wildtype

96.6 (28)

74.5 (117)

p = 0.009

BRAF mutant

BRAF wildtype

PTEN mutant

13.8 (4)

0.0 (0)

(FET)

PTEN wildtype

86.2 (25)

100.0 (157)

p < 0.001

BRAF mutant

BRAF wildtype

PTEN expression negative

37.0 (10)

34.5 (50)

PTEN expression positive

63.0 (17)

65.5 (95)

p = 0.80

BRAF mutant

BRAF wildtype

PIK3CA mutant

13.8 (4)

5.7 (9)

(FET)

PIK3CA wildtype

86.2 (25)

94.3 (148)

p = 0.12

K-RAS mutant

K-RAS wildtype

PIK3CA mutant

7.3 (3)

6.9 (10)

(FET)

PIK3CA wildtype

92.7 (38)

93.1 (135)

p = 1.00

K-RAS mutant

K-RAS wildtype

PTEN mutant

0.0 (0)

2.8 (4)

(FET)

PTEN wildtype

100.0 (41)

97.2 (141)

p = 0.58

K-RAS mutant

K-RAS wildtype

PTEN expression negative

41.7 (15)

33.1 (45)

PTEN expression positive

58.3 (21)

66.9 (91)

p = 0.34

PIK3CA mutant

PIK3CA wildtype

PTEN expression negative

23.1 (3)

35.8 (57)

(FET)

PTEN expression positive

76.9 (10)

64.2 (102)

p = 0.55

PIK3CA mutant

PIK3CA wildtype

PTEN mutant

7.7 (1)

1.7 (3)

(FET)

PTEN wildtype

92.3 (12)

98.3 (170)

p = 0.25