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Table 5 The distribution of PTEN, PIK3CA, BRAF and K-RAS mutations and loss of PTEN expression in the 186 adenocarcinomas available from EPIC Norfolk.

From: Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

  BRAF mutant BRAF wildtype  
K-RAS mutant 3.4 (1) 25.5 (40)  
K-RAS wildtype 96.6 (28) 74.5 (117) p = 0.009
  BRAF mutant BRAF wildtype  
PTEN mutant 13.8 (4) 0.0 (0) (FET)
PTEN wildtype 86.2 (25) 100.0 (157) p < 0.001
  BRAF mutant BRAF wildtype  
PTEN expression negative 37.0 (10) 34.5 (50)  
PTEN expression positive 63.0 (17) 65.5 (95) p = 0.80
  BRAF mutant BRAF wildtype  
PIK3CA mutant 13.8 (4) 5.7 (9) (FET)
PIK3CA wildtype 86.2 (25) 94.3 (148) p = 0.12
  K-RAS mutant K-RAS wildtype  
PIK3CA mutant 7.3 (3) 6.9 (10) (FET)
PIK3CA wildtype 92.7 (38) 93.1 (135) p = 1.00
  K-RAS mutant K-RAS wildtype  
PTEN mutant 0.0 (0) 2.8 (4) (FET)
PTEN wildtype 100.0 (41) 97.2 (141) p = 0.58
  K-RAS mutant K-RAS wildtype  
PTEN expression negative 41.7 (15) 33.1 (45)  
PTEN expression positive 58.3 (21) 66.9 (91) p = 0.34
  PIK3CA mutant PIK3CA wildtype  
PTEN expression negative 23.1 (3) 35.8 (57) (FET)
PTEN expression positive 76.9 (10) 64.2 (102) p = 0.55
  PIK3CA mutant PIK3CA wildtype  
PTEN mutant 7.7 (1) 1.7 (3) (FET)
PTEN wildtype 92.3 (12) 98.3 (170) p = 0.25
  1. P values determined by χ2 test or Fisher's exact test when one or more expected values were less than 5 (denoted by FET). Results presented as % (n). PTEN expression data were not available for 12/186 colorectal adenocarcinomas: these cases were omitted from testing.