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Table 4 Clinicopathological and lifestyle characteristics of PTEN expression negative colorectal cancers stratified by Dukes' stage and colorectal location.

From: Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

  PTEN expression negative colorectal adenocarcinomas
Characteristic Dukes' stage A/B
n= 29
Dukes' stage C/D
n= 23
P Proximal colonic
n= 24
Distal colonic/Rectal
n= 32
P
Sex       
   Male 58.6 (17) 39.1 (9)   41.7 (10) 46.9 (15)  
   Female 41.4 (12) 60.9 (14) 0.16 58.3 (14) 53.1 (17) 0.70
Age at diagnosis (years) 70.3 (8.14) 69.0 (8.67) 0.56 71.0 (7.31) 69.1 (8.77) 0.41
Tumour location       
   Proximal colonic 37.5 (9) 72.0 (18)   a a  
   Distal colonic/Rectal 62.5 (15) 28.0 (7) 0.02 a a a
Differentiation       
   Well/Moderate 92.6 (25) 78.3 (18) (FET) 69.6 (16) 100.0 (28) (FET)
   Poor 7.4 (2) 21.7 (5) 0.23 30.4 (7) 0.0 (0) <0.01
Dukes' Stage       
   A/B a a   37.5 (9) 72.0 (18)  
   C/D a a a 62.5 (15) 28.0 (7) 0.02
MSI status       
   MSS 81.5 (22) 84.2 (16) (FET) 72.7 (16) 89.7 (26) (FET)
   MSI 18.5 (5) 15.8 (3) 1.00 27.3 (6) 10.3 (3) 0.15
BMI (kg/m2) 26.2 (3.60) 26.4 (4.77) 0.85 26.5 (4.71) 26.4 (3.64) 0.93
Alcohol consumption 6.6 (11.1) 6.5 (7.8) 0.97 4.0 (5.7) 8.0 (10.8) 0.11
Smoking status       
   Current 13.8 (4) 4.3 (1)   8.3 (2) 9.4 (3)  
   Former 41.4 (12) 52.2 (12)   54.2 (13) 40.6 (13)  
   Never 44.8 (13) 43.5 (10) 0.47 37.5 (9) 50.0 (16) 0.60
Physical activity       
   Low 69.0 (20) 65.2 (15)   58.3 (14) 78.1 (25)  
   High 31.0 (9) 34.8 (8) 0.78 41.7 (10) 21.9 (7) 0.11
LDL cholesterol (mmol/l) 3.70 (1.05) 3.94 (1.11) 0.45 3.82 (1.17) 3.97 (0.98) 0.62
HDL cholesterol (mmol/l) 1.29 (0.39) 1.33 (0.50) 0.76 1.30 (0.51) 1.34 (0.36) 0.69
Triglyceride (mmol/l) 1.90 (1.21) 2.75 (1.95) 0.06 2.48 (1.61) 1.97 (1.35) 0.21
Plasma vitamin C (μmol/l) 46.6 (18.9) 52.7 (23.1) 0.32 48.1 (19.5) 56.6 (40.1) 0.37
  1. P values determined by χ2 test or Fisher's exact test when one or more expected values were less than 5 (denoted by FET). *: ANOVA tests used to calculate p-values. Results presented as % (n) or mean (±SD). HRT: hormone replacement therapy. MSI: Microsatellite instability. MSS: Microsatellite stable. Not all individuals had data for each variable, in these cases these individuals were omitted from the test. HRT status was not analysed due to the low numbers of cases available for testing. a Testing of Dukes' stage in relation to cancer location in the bowel is presented once per test set.