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Table 4 Clinicopathological and lifestyle characteristics of PTEN expression negative colorectal cancers stratified by Dukes' stage and colorectal location.

From: Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

 

PTEN expression negative colorectal adenocarcinomas

Characteristic

Dukes' stage A/B

n= 29†

Dukes' stage C/D

n= 23†

P ‡

Proximal colonic

n= 24†

Distal colonic/Rectal

n= 32†

P ‡

Sex

      

   Male

58.6 (17)

39.1 (9)

 

41.7 (10)

46.9 (15)

 

   Female

41.4 (12)

60.9 (14)

0.16

58.3 (14)

53.1 (17)

0.70

Age at diagnosis (years)

70.3 (8.14)

69.0 (8.67)

0.56

71.0 (7.31)

69.1 (8.77)

0.41

Tumour location

      

   Proximal colonic

37.5 (9)

72.0 (18)

 

a

a

 

   Distal colonic/Rectal

62.5 (15)

28.0 (7)

0.02

a

a

a

Differentiation

      

   Well/Moderate

92.6 (25)

78.3 (18)

(FET)

69.6 (16)

100.0 (28)

(FET)

   Poor

7.4 (2)

21.7 (5)

0.23

30.4 (7)

0.0 (0)

<0.01

Dukes' Stage

      

   A/B

a

a

 

37.5 (9)

72.0 (18)

 

   C/D

a

a

a

62.5 (15)

28.0 (7)

0.02

MSI status

      

   MSS

81.5 (22)

84.2 (16)

(FET)

72.7 (16)

89.7 (26)

(FET)

   MSI

18.5 (5)

15.8 (3)

1.00

27.3 (6)

10.3 (3)

0.15

BMI (kg/m2)

26.2 (3.60)

26.4 (4.77)

0.85

26.5 (4.71)

26.4 (3.64)

0.93

Alcohol consumption

6.6 (11.1)

6.5 (7.8)

0.97

4.0 (5.7)

8.0 (10.8)

0.11

Smoking status

      

   Current

13.8 (4)

4.3 (1)

 

8.3 (2)

9.4 (3)

 

   Former

41.4 (12)

52.2 (12)

 

54.2 (13)

40.6 (13)

 

   Never

44.8 (13)

43.5 (10)

0.47

37.5 (9)

50.0 (16)

0.60

Physical activity

      

   Low

69.0 (20)

65.2 (15)

 

58.3 (14)

78.1 (25)

 

   High

31.0 (9)

34.8 (8)

0.78

41.7 (10)

21.9 (7)

0.11

LDL cholesterol (mmol/l)

3.70 (1.05)

3.94 (1.11)

0.45

3.82 (1.17)

3.97 (0.98)

0.62

HDL cholesterol (mmol/l)

1.29 (0.39)

1.33 (0.50)

0.76

1.30 (0.51)

1.34 (0.36)

0.69

Triglyceride (mmol/l)

1.90 (1.21)

2.75 (1.95)

0.06

2.48 (1.61)

1.97 (1.35)

0.21

Plasma vitamin C (μmol/l)

46.6 (18.9)

52.7 (23.1)

0.32

48.1 (19.5)

56.6 (40.1)

0.37

  1. ‡P values determined by χ2 test or Fisher's exact test when one or more expected values were less than 5 (denoted by FET). *: ANOVA tests used to calculate p-values. Results presented as % (n) or mean (±SD). HRT: hormone replacement therapy. MSI: Microsatellite instability. MSS: Microsatellite stable. † Not all individuals had data for each variable, in these cases these individuals were omitted from the test. HRT status was not analysed due to the low numbers of cases available for testing. a Testing of Dukes' stage in relation to cancer location in the bowel is presented once per test set.