Table 1 The type and distribution of mutations in PTEN exons 7 and 8 and PIK3CA exons 8, 9 and 20 in 186 adenocarcinoma and 16 adenoma samples available from EPIC Norfolk.

Codon 233: wildtype CGA*

TGA (Arg to Stop)

1

0

1

Codon 339: wildtype CCA*

TCA (Phe to Ser)

1

0

1

Poly-A tract (codons 321-323)

1 bp insertion

1

0

1

Poly-A tract (codons 321-323)

1 bp deletion

1

0

1

Codon 316 (1 ^st base) to 323 (2 ^nd base)

23 bp deletion

1

0

1

Total

5

0

5

PIK3CA mutations in exons 8, 9 and 20

Mutations in adenocarcinomas

Mutations in adenomas

Total

Codon 542: wildtype GAA

GTA (Glu to Val)

1

0

1

AAA (Glu to Lys)

2

0

2

Codon 545: wildtype GAG

AAG (Glu to Lys)

2

1

3

Codon 546: wildtype CAG

AAG (Gln to Lys)

2

0

2

CGG (Gln to Arg)

1

0

1

Codon 1046: wildtype CAT

CGT (His to Arg)

5

0

5

Total

13

1

14