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Table 1 The type and distribution of mutations in PTEN exons 7 and 8 and PIK3CA exons 8, 9 and 20 in 186 adenocarcinoma and 16 adenoma samples available from EPIC Norfolk.

From: Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

  PTEN mutations in exons 7 and 8
  Mutations in adenocarcinomas Mutations in adenomas Total
Codon 233: wildtype CGA*    
TGA (Arg to Stop) 1 0 1
Codon 339: wildtype CCA*    
TCA (Phe to Ser) 1 0 1
Poly-A tract (codons 321-323)    
1 bp insertion 1 0 1
Poly-A tract (codons 321-323)    
1 bp deletion 1 0 1
Codon 316 (1 st base) to 323 (2 nd base)    
23 bp deletion 1 0 1
Total 5 0 5
  PIK3CA mutations in exons 8, 9 and 20
  Mutations in adenocarcinomas Mutations in adenomas Total
Codon 542: wildtype GAA    
GTA (Glu to Val) 1 0 1
AAA (Glu to Lys) 2 0 2
Codon 545: wildtype GAG    
AAG (Glu to Lys) 2 1 3
Codon 546: wildtype CAG    
AAG (Gln to Lys) 2 0 2
CGG (Gln to Arg) 1 0 1
Codon 1046: wildtype CAT    
CGT (His to Arg) 5 0 5
Total 13 1 14
  1. *These two mutations were observed in the same adenocarcinoma.