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Table 1 Patient characteristics (n = 221)

From: Carbonic anhydrase IX in tumor tissue and sera of patients with primary cervical cancer

   (%)
Age (years)   
Median 47  
Mean 49  
Range 23 - 85  
Histological subtype (n = 221)   
Squamous cell carcinoma 161 (72.9)
Adenocarcinoma 35 (15.8)
Adenosquamous cell carcinoma 25 (11.3)
Tumor stage (FIGO) (n = 221)   
Ia1 0 (0.0)
Ia2 3 (1.4)
Ib1 113 (51.1)
Ib2 20 (9.0)
IIa 17 (7.7)
IIb 44 (19.9)
IIIa 0 (0.0)
IIIb 1 (0.5)
IVa 7 (3.2)
IVb 16 (7.2)
Lymph node involvement (n = 221)   
N0 168 (76.0)
N1 53 (24.0)
Removed lymph nodes (n = 221)   
Median 27  
Mean 30  
Range 2 - 88  
Affected lymph nodes (n = 53)   
Median 2  
Mean 3  
Range 1 - 14  
Distant metastasis (n = 181)   
M0 165 (91.2)
M1 16 (8.8)
Tumor grade (n = 215)   
G1 9 (4.2)
G2 95 (44.2)
G3 111 (51.6)
Lymphovascular space invasion (n = 196)   
L0 64 (32.7)
L1 132 (67.3)
Vascular invasion (n = 169)   
V0 151 (89.3)
V1 18 (10.7)
Surgical therapy (n = 181)   
Radical hysterectomy 180 (99.5)
Trachelectomy 1 (0.5)
Preoperative SCC serum concentration (μg/l) (n = 144)   
Median value 1.4  
Mean 5.2  
Range 0.2 - 107.0  
Adjuvant Therapy (n = 180)   
No therapy 88 (48.9)
Adjuvant radiotherapy 44 (24.4)
Adjuvant concomitant chemoradiotherapy 48 (26,7)
Follow-up (months) (n = 175)   
Median 49  
Mean 63  
Range 2-193  
Disease free surviving 131 (74.9)
Disease recurrence 44 (25.1)
Died of disease 38 (21.7)
CAIX expression (IRS) (n = 221)   
Median expression 2  
Mean 3  
Range 0 - 12  
IRS 0 40 18.1
IRS 1 44 19.9
IRS 2 35 15.8
IRS 3 9 4.1
IRS 4 32 14.5
IRS 6 29 13.1
IRS 8 2 0.9
IRS 9 23 10.4
IRS 12 7 3.2
CAIX serum concentration (pg/mL) (n = 46)   
Median concentration 104  
Mean 137  
Range 23-499  
  1. IRS: Immunoreactive score (IRS) according to W. Remmele and H. E. Stegner