A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival

Table 4 Results of ovarian cancer survival analysis for the KLK15 rs266851 SNP in Australian, UK GWAS data, TCGA data and the combined datasets

KLK15rs266851	n	n censored	Adjusted* HR (95% CI)*
*Australian*
CC	222	128	1.0
CT/TT	96	60	1.42 (1.02-1.96)
UK GWAS**
CC	1139	390	1.0
CT/TT	676	221	1.07 (0.94-1.24)
TCGA***
CC	280	135	1.0
CT/TT	133	76	1.20 (0.90-1.61)
*Combined Analysis*
CC	1641	653	1.0
CT/TT	905	357	1.16 (1.00-1.34)

*Adjusted for age, FIGO stage, histological subtype, and grade.
**The UK GWAS dataset was adjusted for age, FIGO stage, histologic subtype, grade and study site.
***The TCGA dataset was adjusted for age, FIGO stage and histologic grade, but not subtype as all the samples were of the serous subtype.

ISSN: 1471-2407