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Table 4 Results of ovarian cancer survival analysis for the KLK15 rs266851 SNP in Australian, UK GWAS data, TCGA data and the combined datasets

From: A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival

KLK15rs266851 n n censored Adjusted* HR (95% CI)*
Australian    
CC 222 128 1.0
CT/TT 96 60 1.42 (1.02-1.96)
UK GWAS**    
CC 1139 390 1.0
CT/TT 676 221 1.07 (0.94-1.24)
TCGA***    
CC 280 135 1.0
CT/TT 133 76 1.20 (0.90-1.61)
Combined Analysis    
CC 1641 653 1.0
CT/TT 905 357 1.16 (1.00-1.34)
  1. *Adjusted for age, FIGO stage, histological subtype, and grade.
  2. **The UK GWAS dataset was adjusted for age, FIGO stage, histologic subtype, grade and study site.
  3. ***The TCGA dataset was adjusted for age, FIGO stage and histologic grade, but not subtype as all the samples were of the serous subtype.
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BMC Cancer

ISSN: 1471-2407

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