Table 2 Cytotoxic effect of LTX-302, LTX-315 and LTX-318 against HT-29, MT-1, Kelly, HUVEC, MRC-5 and RBC
From: Small lytic peptides escape the inhibitory effect of heparan sulfate on the surface of cancer cells
Peptide | HT-29 a IC 50 (μM) | MT-1 IC 50 (μM) | Kelly IC 50 (μM) | HUVEC IC 50 (μM) | MRC-5 IC 50 (μM) | RBC IC 50 (μM) |
|---|---|---|---|---|---|---|
LTX-302 | 75 ± 5 | 73 ± 2 | 28 ± 0 | 123 ± 9 | 126 ± 11 | > 695d |
LTX-315 | 38 ± 3 | 31 ± 3 | 14 ± 1 | 28 ± 1 | 41 ± 3 | > 695 |
LTX-318 | 248 ± 5 | 216 ± 36 | 78 ± 7 | > 347c | > 347c | > 695 |
LfcinB | > 160b | > 160 | 141 ± 3 | > 160 | > 160 | > 500e |