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Figure 4 | BMC Cancer

Figure 4

From: Replicase-based plasmid DNA shows anti-tumor activity

Figure 4

Treatment of mice with the pSIN-β caused TC-1 tumor regression. (A). C57BL/6 mice (n = 5) were s.c. implanted with TC-1 tumor cells (5 × 105) on day 0. DNA-liposome lipoplexes were injected (s.c., p.t.) for 10 consecutive days, starting on day 5 (25 μg DNA per day). (*) indicates that on days 13-15 the values of pCMV-β and pSIN-β were different from each other (p < 0.05). (B). Peritumoral injection of liposomes alone or sterile PBS did not affect the growth of the TC-1 tumors. Mice (n = 5) with TC-1 tumors were injected (p.t.) with sterile PBS or liposomes in PBS (dose equivalent to that injected in the DNA-liposome lipoplexes) for 10 consecutive days, starting on day 4. Data shown were mean ± S.E.M.

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