Figure 10

pSIN-β was more effective than pCMV-β in controlling the growth of mouse B16-F10 and B16-OVA melanomas as well. C57BL/6 mice (n = 6-7) were implanted with B16-F10 ( A) or B16-OVA (B) cells on day 0. DNA-liposome lipoplexes were injected (s.c., p.t.) for 10 consecutive days starting on day 3 (25 μg DNA per day). (*) indicate that on days 9-12 for B16-F10 (or days 9-11 for B16-OVA), the values of pCMV-β and pSIN-β were different from each other (p < 0.05). Data shown are mean ± S.E.M.