Status of ABI3 expression in thyroid tumors and in carcinomas cell lines. (A) ABI3 expression is reduced in most thyroid malignant tumors (p < 0.001). (B) A positive correlation was observed between levels of ABI3 and ABI3BP expression in the panel of thyroid samples, mainly in malignant tumors. (C) ABI3 expression in control cells (cells transfected with empty vector) or clones expressing ABI3 (two of each cell line). (D) ABI3 ectopic expression reduced focus formation. The data represents the mean ± SD of the experiment performed in triplicates. FTA, Follicular thyroid adenomas; HCA, Hürthle cell adenomas; FTC, follicular thyroid carcinomas; HCC, Hürthle cell carcinomas; PTC, papillary thyroid carcinomas. *p <0.05, **p < 0.01, ***p≤ 0.001.