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Table 4 Associations between APE1/Ref-1 rs1760944 and risk of different histological types of gliomas

From: A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population

rs1760944

Controls (824)

Glioblastoma (241)

 

Astrocytomas (284)

 

Other gliomas (241)

 

No. (%)

No. (%)

P a

OR (95% CI) b

P c

No. (%)

P a

OR (95% CI) b

P c

No. (%)

P a

OR (95% CI) b

P c

Alleles

             

T

898 (55.0)

286 (60.6)

0.032

1.00 (reference)

0.032

309 (55.6)

0.821

1.00 (reference)

0.821

263 (55.7)

0.783

1.00 (reference)

0.783

G

734 (45.0)

186 (39.4)

 

0.80 (0.65-0.98)

 

247 (44.4)

 

0.98 (0.81-1.19)

 

209 (44.3)

 

0.97 (0.79-1.19)

 

Genotypes

             

TT

237 (29.0)

81 (34.3)

0.041

1.00 (reference)

 

86 (30.9)

0.634

1.00 (reference)

 

66 (28.0)

0.592

1.00 (reference)

 

TG

424 (52.0)

124 (52.6)

 

0.84 (0.60-1.17)

0.298

137 (49.3)

 

0.87(0.64-1.19)

0.390

131(55.5)

 

1.11(0.79-1.56)

0.539

GG

155 (19.0)

31 (13.1)

 

0.54 (0.34-0.87)

0.012

55 (19.8)

 

0.99(0.66-1.47)

0.950

39 (16.5)

 

0.91(0.58-1.43)

0.686

   

P d for trend = 0.014

P d for trend = 0.832

P d for trend = 0.813

  1. aAllele and genotype frequencies in cases and controls were compared using χ2 test.
  2. bAllele-specific ORs were not adjusted; genotype-specific ORs were adjusted for age and gender.
  3. c P value from unconditional logistic regression analyses.
  4. dTrend tests were calculated using the genotype as an ordinal variable in the regression model.