Genetic and epigenetic silencing of the beclin 1gene in sporadic breast tumors

BMC Cancer

Table 5 Beclin 1 mRNA and protein expression, p53, BRCA1 and BRCA2 protein expression and LOH analysis of beclin 1 in breast cancer tissues

Breast cancer cases	Beclin 1 mRNA expression	Protein expression				LOH (Q-PCR)	LOH (microsatellite)
		Beclin 1	P53	BRCA1	BRCA2
1	-	-	-	-	-	+	+
2	+	+	-	+	+	-	-
3	-	-	-	-	-	+	+
4	-	-	-	-	+	+	-+
5	+	+	-	+	-	-	-
6	-	-	-	+	+	+	+
7	-	-	-	+	+	+	+
8	-	-	-	-	-	+	+
9	+	+	-	-	-	-	-
10	-	-	-	+	-	-	-
11	+	+	+	-	+	+	+
12	-	-	-	-	-	+	+
13	-	-	-	-	+	+	+
14	-	-	-	-	-	+	+
15	+	+	-	-	-	-	-
16	-	-	-	-	-	-	-
17	+	+	+	+	+	+	-
18	-	+	-	-	-	-	-
19	-	-	-	-	+	-	-
20	-	-	-	-	+	-	-

ISSN: 1471-2407