Quantitative methylation profiling in tumor and matched morphologically normal tissues from breast cancer patients

Table 2 DNA methylation of 6 genes associated with breast carcinogenesis in normal and cancerous breast tissues.

Gene	Normal tissue from unaffected women (N = 9)	Normal tissue from cancer patients (N = 56)	Cancerous tissue (N = 56)	P-value^a	P-value^b
DAPK	0.47 (0.00-2.51)	0.30 (0.00-690.19)	0.92 (0.00-1445.43)	0.56	0.34
TWIST	0.00 (0.00-1.78)	0.00 (0.00-388.92)	0.00 (0.00-1066.79)	0.06	0.03
HIN-1	0.00 (0.00-0.00)	0.00 (0.00-296.26)	199.46 (0.00-2627.44)	0.31	0.003
RASSF1A	0.74 (0.19-103.25)	11.15 (0.00-418.42)	348.80 (0.00-1241.21)	0.03	<0.001
RARβ2	0.00 (0.00-0.00)	0.00 (0.00-183.29)	0.00 (0.00-977.59)	0.04	0.07
APC	0.00 (0.00-0.00)	0.00 (0.00-1992.07)	163.97 (0.00-4481.91)	0.04	0.004

ISSN: 1471-2407