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Figure 6 | BMC Cancer

Figure 6

From: The investigation of Mitogen-Activated Protein kinase Phosphatase-1 as a potential pharmacological target in non-small cell lung carcinomas, assisted by non-invasive molecular imaging

Figure 6

Proposed pharmacological role of MKP-1 in rosiglitazone-mediated tumour suppression. Rosiglitazone exerts its anti-tumour effects via both PPARγ-dependent (via CXCR4) and PPARγ-independent (via MKP-1 induction) pathways Two major MAPKs affected by the induction of MKP-1 are p38 and ERK which participate in the regulation of cellular mobility and proliferation respectively (→ direct stimulatory modification; --> tentative stimulatory modification; --| direct inhibitory modification).

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BMC Cancer

ISSN: 1471-2407

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