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Figure 3 | BMC Cancer

Figure 3

From: The investigation of Mitogen-Activated Protein kinase Phosphatase-1 as a potential pharmacological target in non-small cell lung carcinomas, assisted by non-invasive molecular imaging

Figure 3

MKP-1 regulates invasive and migratory abilities in NSCLC H441GL cells. Cell invasive (A) and migratory (B) abilities of H441GL cells were examined under the presence of different inhibitors of MAPKs (all at 30 μM) including p38 MAPK (SB203580), ERK1/2 (PD98059), and JNK (SP600125) inhibitors The degree of inhibition in H441GL invasiveness (C) and migration (D) when MKP-1 was over-expressed was examined The inhibition of invasiveness and migration was found at the following order, p38>ERK>JNK and p38ERK>JNK respectively Data represent mean ± SD (n = 3).

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