Skip to main content

Table 3 VEGF-C/VEGFR3, VEGF-D/VEGFR2, and VEGF-D/VEGFR3 ratios and association with clinico-pathological features in mismatch repair-proficient colorectal cancer.

From: Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer

  

VEGF-C/VEGFR3

VEGF-D/VEGFR2

VEGF-D/VEGFR3

   

P-value

 

P-value

 

P-value

TNM stage

I+II

6.0 ± 21.0;

0.95

0.265

1.8 ± 9.1;

1.0

0.55

6.6 ± 22.4;

1.03

0.981

 

III

3.99 ± 13.4;

0.79

 

0.94 ± 0.1;

1.0

 

13.2 ± 32.0;

1.05

 
 

IV

5.93 ± 19.7;

1.0

 

4.67 ± 18.8;

1.0

 

7.14 ± 23.3;

1.05

 

Tumour grade

G1-2

5.28 ± 18.3;

0.95

0.116

2.46 ± 11.9;

1.0

0.274

8.34 ± 25.4;

1.05

0.317

 

G3

4.94 ± 18.1;

0.75

 

0.96 ± 0.17;

1.0

 

11.9 ± 30.5;

1.0

 

Vascular invasion

Absent

4.56 ± 16.8;

0.95

0.928

2.2 ± 10.5;

1.0

0.53

8.75 ± 26.2;

1.0

0.158

 

Present

6.74 ± 21.4;

0.95

 

2.34 ± 11.6;

1.0

 

9.7 ± 27.1;

1.05

 

Tumour border configuration

PM

3.9 ± 15.7;

0.95

0.349

1.82 ± 9.04;

1.0

0.172

7.62 ± 24.5;

1.0

0.437

 

IM

6.67 ± 20.7;

0.95

 

2.53 ± 12.3;

1.0

 

10.5 ± 28.3;

1.05

 

PTL infiltration

Absent

6.15 ± 20.1;

0.95

0.733

1.96 ± 9.9;

1.0

0.538

10.6 ± 28.9;

1.0

0.575

 

Present

1.09 ± 1.5;

0.85

 

3.18 ± 14.4;

1.0

 

1.79 ± 3.0;

1.05

 
  1. Mean ± SD, median values. Kruskal-Wallis or Wilcoxon Rank Sum Test. PM = pushing/expanding margin; IM = infiltrating margin; PTL = peritumoral lymphocytic.