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Table 3 VEGF-C/VEGFR3, VEGF-D/VEGFR2, and VEGF-D/VEGFR3 ratios and association with clinico-pathological features in mismatch repair-proficient colorectal cancer.

From: Role of the VEGF ligand to receptor ratio in the progression of mismatch repair-proficient colorectal cancer

   VEGF-C/VEGFR3 VEGF-D/VEGFR2 VEGF-D/VEGFR3
    P-value   P-value   P-value
TNM stage I+II 6.0 ± 21.0; 0.95 0.265 1.8 ± 9.1; 1.0 0.55 6.6 ± 22.4; 1.03 0.981
  III 3.99 ± 13.4; 0.79   0.94 ± 0.1; 1.0   13.2 ± 32.0; 1.05  
  IV 5.93 ± 19.7; 1.0   4.67 ± 18.8; 1.0   7.14 ± 23.3; 1.05  
Tumour grade G1-2 5.28 ± 18.3; 0.95 0.116 2.46 ± 11.9; 1.0 0.274 8.34 ± 25.4; 1.05 0.317
  G3 4.94 ± 18.1; 0.75   0.96 ± 0.17; 1.0   11.9 ± 30.5; 1.0  
Vascular invasion Absent 4.56 ± 16.8; 0.95 0.928 2.2 ± 10.5; 1.0 0.53 8.75 ± 26.2; 1.0 0.158
  Present 6.74 ± 21.4; 0.95   2.34 ± 11.6; 1.0   9.7 ± 27.1; 1.05  
Tumour border configuration PM 3.9 ± 15.7; 0.95 0.349 1.82 ± 9.04; 1.0 0.172 7.62 ± 24.5; 1.0 0.437
  IM 6.67 ± 20.7; 0.95   2.53 ± 12.3; 1.0   10.5 ± 28.3; 1.05  
PTL infiltration Absent 6.15 ± 20.1; 0.95 0.733 1.96 ± 9.9; 1.0 0.538 10.6 ± 28.9; 1.0 0.575
  Present 1.09 ± 1.5; 0.85   3.18 ± 14.4; 1.0   1.79 ± 3.0; 1.05  
  1. Mean ± SD, median values. Kruskal-Wallis or Wilcoxon Rank Sum Test. PM = pushing/expanding margin; IM = infiltrating margin; PTL = peritumoral lymphocytic.