Favourable ten-year overall survival in a Caucasian population with high probability of hereditary breast cancer

BMC Cancer

Table 2 Cox's proportional hazard regression models for overall survival

Variable	N° (%)	HR	p	[95% CI]
All cases	5012 (85)
Sporadic	4172 (83)	1.00	-	-
BRCA -	785 (16)	0.76	< .001	0.64 to 0.89
BRCA1+	55 (1)	0.29	.002	0.13 to 0.62
stage > 1	2372 (47)	3.49	< .0001	3.01 to 4.04
Estrogen receptor positive	4090 (82)	0.82	.03	0.69 to 0.98
Progesterone receptor positive	3138 (64)	0.79	.004	0.67 to 0.93
Chemotherapy, yes	2213 (44)	0.68	< .0001	0.59 to 0.77
Age ≤ 35	199 (4)	1.12	.42	0.84 to 1.49
Grading III	1778 (35)	1.39	< .0001	1.22 to 1.58
Model with chemotherapy	2213 (44)
Sporadic	1780 (36)	1.00	-	-
BRCA-	404 (8)	0.97	0.79	0.78 to 1.20
BRCA1+	29 (2)	0.38	.05	0.14 to 0.99
Stage > I	1689 (76)	3.55	< .0001	2.65 to 4.76
Estrogen receptor positive	1571 (71)	0.81	.083	0.65 to 1.02
Progesterone receptor positive	1492 (67)	0.76	.021	0.61 to 0.96
Age ≤ 35 years	128 (6)	1.15	.44	0.81 to 1.62
Grading III	1116 (50)	1.38	< .0001	1.15 to 1.64
Model without chemotherapy	2799 (56)
Sporadic	2392 (85)	1.00	-	-
BRCA-	381 (14)	0.56	< .0001	0.43 to 0.73
BRCA1+	26 (1)	0.23	.056	0.14 to 1.02
stage > I	951 (34)	3.43	< .0001	2.89 to 4.09
Estrogen receptor positive	2519 (90)	0.82	.17	0.63 to 1.08
Progesterone receptor positive	2298 (82)	0.82	.08	0.65 to 1.03
Age ≤ 35	71 (3)	0.95	.85	0.56 to 1.60
Grading III	662 (24)	1.39	< .0001	1.15 to 1.68

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