Figure 8

Expression of NM23-H1 in normal, BH, DCIS and IBC tissue. A. Tissues were subjected to IHC using an NM23-H1-specific antibody. Representative slides are shown at 40× magnification. B. The relative mean intensity was determined from 6-8 images for each BH (n = 16), DCIS (n = 16) or IBC (n = 25) section and is shown graphically. ANOVA was used to detect statistical differences in the relative expression of BH, DCIS (p = 0.0019) and IBC (p < 0.0001) compared to normal mammary tissue, where normal mammary tissue is equal to one (dashed line). C. The relative mean intensity of IBC tissues was graphed according to nodal-status.