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Table 2 Risk of lung cancer in relation to MDM2 SNP309 and p53 codon 72 polymorphisms

From: Effect of MDM2 SNP309 and p53 codon 72 polymorphisms on lung cancer risk and survival among non-smoking Chinese women in Singapore

Genotype   Cases (n = 123) Controls (n = 159) Age- and birthplace-adjusted1odds ratio (95% CI)
   No. (%) No. (%)  
MDM2 SNP309     
   GG   29 (23.6) 51 (32.1) 1.00
   TG   65 (52.8) 83 (52.2) 1.42 (0.80-2.52)
   TT   29 (23.6) 25 (15.7) 2.10 (1.01-4.36)
P53 codon 72     
   Arg/Arg   28 (22.8) 42 (26.1) 1.00
   Arg/Pro   69 (56.1) 88 (54.7) 1.21 (0.67-2.17)
   Pro/Pro   26 (21.1) 31 (19.3) 1.44 (0.70-3.00)
Combined genotype2     
P53 codon 72 MDM2 SNP309    
Arg/Arg GG/TG 24 (85.7%) 32 (76.2%) 1.00
  TT 4 (14.3%) 10 (23.8%) 0.58 (0.15-2.22)
ArgPro/ProPro GG/TG 69 (73.4%) 102 (87.2%) 1.00
  TT 25 (26.6%) 15 (12.8%) 2.42 (1.16-5.03)
  1. 1 Adjusted for age in years and birthplace (China-born, Singapore/Malaysia-born). All individuals were lifetime non-smoker Chinese women.
  2. 2 P (interaction) = 0.06