Effect of MDM2 SNP309 and p53 codon 72 polymorphisms on lung cancer risk and survival among non-smoking Chinese women in Singapore

Table 2 Risk of lung cancer in relation to MDM2 SNP309 and p53 codon 72 polymorphisms

Genotype		Cases (n = 123)	Controls (n = 159)	Age- and birthplace-adjusted¹odds ratio (95% CI)
		No. (%)	No. (%)
MDM2 SNP309
GG		29 (23.6)	51 (32.1)	1.00
TG		65 (52.8)	83 (52.2)	1.42 (0.80-2.52)
TT		29 (23.6)	25 (15.7)	2.10 (1.01-4.36)
P53 codon 72
Arg/Arg		28 (22.8)	42 (26.1)	1.00
Arg/Pro		69 (56.1)	88 (54.7)	1.21 (0.67-2.17)
Pro/Pro		26 (21.1)	31 (19.3)	1.44 (0.70-3.00)
Combined genotype²
P53 codon 72	MDM2 SNP309
Arg/Arg	GG/TG	24 (85.7%)	32 (76.2%)	1.00
	TT	4 (14.3%)	10 (23.8%)	0.58 (0.15-2.22)
ArgPro/ProPro	GG/TG	69 (73.4%)	102 (87.2%)	1.00
	TT	25 (26.6%)	15 (12.8%)	2.42 (1.16-5.03)

¹ Adjusted for age in years and birthplace (China-born, Singapore/Malaysia-born). All individuals were lifetime non-smoker Chinese women.
² P (interaction) = 0.06

ISSN: 1471-2407