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Figure 4 | BMC Cancer

Figure 4

From: Pancreatic adenocarcinoma exerts systemic effects on the peripheral blood myeloid and plasmacytoid dendritic cells: an indicator of disease severity?

Figure 4

Increased spontaneous apoptosis among the MDCs and PDCs in individuals with PDAC and other types pancreatic cancers. (A) Percentage apoptotic MDCs (top panel) and PDCs (lower panel) of total MDCs and PDCs prior tumor resection in controls, pancreatic duct adenocarcinoma (PDAC), none resectable pancreatic tumor (NRPT), billary duct adenocarcinoma (BDAC), ampullary carcinoma (AC), endocrine carcinoma (EC), and chronic pancreatitis (CP). Percent apoptotic MDCs (top) and PDCs (bottom) of total MDCs and PDCs in healthy age match controls and pre and post tumor resection in individuals with PDAC (B), AC (C), EC (D) and CP (E). Correlation between percent apoptotic MDCs and level of MDCs (left) and correlation between percent apoptotic PDCs and level of PDCs (right) in individuals with PDAC pre tumor resection (F) and post tumor resection (G). The numbers of Annexin V positive MDCs and PDCs were measured as the percentage of Annexin V+ cells out of the total amount of MDCs or PDCs. Statistically significant differences between individuals with pancreatic disease and healthy controls are indicated as; * = p < 0.05, ** = p < 0.005, *** = p < 0.001.

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