Figure 4
From: Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases
(a) Real Time PCR: Downregulation of FAS gene expression from day 10 on following an initial increase but steadily increasing of FAS-L gene expression in metastatic liver over time (day 5, 10, 15 and 20) following intraportal injection of 1 × 10 5 CT26.WT cells. Analysis was measured to control tissue (liver). (b) Immunohistochemistry: Increasing number (in %) of FAS-L expressing tumor cells but a decreased FAS expression from day 10 on following intraportal injection of 1 × 105 CT26.WT cells.