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Table 4 Genes showing an association between copy number and expression in gastric cancer.

From: Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines

Gene

Chromosome

Fold change cancer vs. normal

p-value cancer vs. normal

Fold change g1 vs. g0

p-value g1 vs. g0

Previous reports in gastric cancer

PubMed IDs

ALPK2

18q21.31-q21.32

1.9

p < 0.05

-2.9

p < 0.05

-

-

CYP3A4

7q21.1

8.9

p < 0.001

2.4

p < 0.05

polymorphisms

17605821

ENAH

1q42.12

8.4

p < 0.001

3.8

p < 0.05

-

-

ERBB2

17q21.1

3.5

p < 0.001

1.8

p < 0.05

amplification and overexpression

14991576, 19156142, 17555797

HHIPL2

1q41

7.4

p < 0.05

17.4

p < 0.05

-

 

MMP9

20q11.2-q13.1

4.8

p < 0.001

1.7

p < 0.05

overexpression, polymorphisms

18437914, 18451255, 16237750

OSMR

5p13.1

3.4

p < 0.001

2.4

p < 0.05

-

-

PERLD1

17q12

3.4

p < 0.001

3.0

p < 0.05

amplification and overexpression

16849520

PTPRA

20p13

4.1

p < 0.001

1.3

p < 0.05

overexpression

16338072

  1. Gene expression fold changes according to the qRT-PCR and TRAC analyses and p-values from nonparametrical Mann-Whitney test are shown (SPSS 17.0). g1, gastric cancer samples with copy number gain/loss; g0, gastric cancer samples with normal copy number.