Table 2 Minimal common regions of recurrent (≥25%) copy number alterations.
Alteration | Tissues (n = 13) | Cell lines (n = 7) | Frequency | Size (Mb) | Position (Mb) | Possible target genes |
|---|---|---|---|---|---|---|
+1q41-q43.1 | 2 | 3 | 25% | 17.30 | 216.31-233.61 | ENAH, AGT, CAPN2, LEFTY2, LGALS8 |
+5p13.3-q11.1 | 1 | 4 | 25% | 19.41 | 30.18-49.60 | OSMR, RNASEN |
+7q21.3-q22.1 | 4 | 3 | 35% | 4.60 | 97.33-101.93 | CYP3A4, AZGP1, VGF |
+8q24.13-q24.3 | 3 | 2 | 25% | 19.8 | 126.45-146.25 | ASAP1, BAI1, KHDRBS3 |
+8q24.3 | 6 | 3 | 45% | 2.23 | 143.59-145.82 | GML, LYPD, AK3 |
+14q11.2 | 0 | 5 | 25% | 1.05 | 22.89-23.94 | LTB4R |
+17q12-q21.1 | 3 | 3 | 30% | 0.28 | 35.02-35.30 | ERBB2, PPP1R1B, PERLD1, PNMT |
+17q22-q24.2 | 2 | 3 | 25% | 13.65 | 50.45-64.10 | AXIN2, RNF43 |
+19q12-qter | 4 | 3 | 35% | 29.36 | 33.89-63.25 | CEACAM5, APOC1, APOE, CEACAM7, FTL, FUT1, GPR4, HPN, KCNN4, KLK1, KLK12, LYPD3, NLRP7, CCNE1 |
+20p13-qter | 5 | 3 | 40% | 57.94 | 0.04-57.98 | PTPRA, BLCAP, CD40, CHGB, CST3, EYA2, PI3, ID1, MMP9, BMP7 |
-9p24.3-p21.1 | 3 | 4 | 35% | 27.81 | 1.05-28.86 | MTAP, CD274, INSL4, JAK2, MLANA, SMARC2, TUSC1 |
-18q12.3-q22.2 | 3 | 5 | 40% | 26.11 | 39.48-65.59 | SMAD7, SERPINB2/B3/B4/B5 |
-18q22.3-qter | 2 | 5 | 35% | 3.69 | 70.95-74.65 | TSHZ1 |
-21q11.2-q21.1 | 3 | 3 | 30% | 4.07 | 14.37-19.44 | HSPA13 |
-Xq28 | 4 | 1 | 25% | 1.21 | 152.24-153.45 | - |