Table 2 Gene expression changes in HeLaNR and HeLaXR cell lines (≥2-fold)
GeneBank | Symbol | Gene Function | Regulation Mode | |
|---|---|---|---|---|
| Â | Â | Â | HeLaNR* | HeLaXR* |
NM_000051 | ATM | Other genes involved in DNA repair | Â | up |
NM_006763 | BTG2 | Other genes involved in DNA repair | up | Â |
NM_001279 | CIDEA | Apoptosis genes | up | up |
NM_014430 | CIDEB | Apoptosis genes | up | up |
NM_000082 | CKN1 | Nucleotide excision repair | up | Â |
NM_001923 | DDB1 | Nucleotide excision repair | up | up |
NM_007068 | DMC1 | Nucleotide excision repair | Â | up |
NM_005236 | ERCC4 | Nucleotide excision repair | up | Â |
NM_006705 | GADD45G | Apoptosis genes | up | Â |
NM_001515 | GTF2H2 | Nucleotide excision repair | up | Â |
NM_016426 | GTSE1 | Cell cycle arrest | Â | up |
NM_004507 | HUS1 | Cell cycle arrest | Â | up |
NM_054111 | IHPK3 | Apoptosis genes | up | Â |
NM_001567 | INPPL1 | Other genes involved in DNA repair | up | up |
NM_033276 | KUB3 | Nonhomologous end-joining | up | up |
NM_000234 | LIG1 | Nucleotide excision repair | Â | up |
NM_002758 | MAP2K6 | Cell cycle arrest | Â | up |
NM_002969 | MAPK12 | Cell cycle arrest | up | up |
NM_005590 | MRE11A | Homologous recombination | Â | up |
NM_018177 | N4BP2 | Other genes involved in DNA repair | Â | up |
NM_002528 | NTHL1 | Base excision repair | up | up |
NM_020418 | PCBP4 | Apoptosis genes | Â | up |
D38500 | PMS2L4 | Mismatch repair | Â | up |
NM_005395 | PMS2L9 | Mismatch repair | Â | up |
NM_007254 | PNKP | Base excision repair | up | up |
NM_014330 | PPP1R15A | Apoptosis genes | Â | up |
NM_006904 | PRKDC | Nonhomologous end-joining | Â | up |
NM_002873 | RAD17 | Cell cycle arrest | Â | up |
NM_006265 | RAD21 | Apoptosis genes | up | Â |
NM_005053 | RAD23A | Nucleotide excision repair | Â | up |
NM_002875 | RAD51 | Homologous recombination | Â | up |
NM_133509 | RAD51L1 | Homologous recombination | Â | up |
NM_002878 | RAD51L3 | Homologous recombination | Â | up |
NM_002879 | RAD52 | Homologous recombination | up | up |
NM_003579 | RAD54L | Homologous recombination | Â | up |
NM_004584 | RAD9A | Cell cycle arrest | Â | up |
NM_016316 | REV1L | Other genes involved in DNA repair | Â | up |
NM_000546 | TP53 | Apoptosis genes | Â | up |
NM_016381 | TREX1 | Mismatch repair | Â | up |
NM_007205 | TREX2 | Other genes involved in DNA repair | Â | up |
NM_003362 | UNG | Base excision repair | up | up |
NM_021147 | UNG2 | Base excision repair | up | up |
NM_005431 | XRCC2 | Homologous recombination | Â | up |
NM_005432 | XRCC3 | Homologous recombination | up | up |
NM_003401 | XRCC4 | Nonhomologous end-joining | Â | up |
NM_001239 | CCNH | Nucleotide excision repair | Â | down |
NM_004083 | DDIT3 | Cell cycle arrest | down | down |
NM_001924 | GADD45A | Apoptosis genes | down | down |
NM_002311 | LIG3 | Base excision repair | down | Â |
NM_000534 | PMS1 | Mismatch repair | down | Â |
NM_002873 | RAD17 | Cell cycle arrest | down | Â |